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The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice

Insulin stimulates glucose uptake in adult skeletal muscle by promoting the translocation of GLUT4 glucose transporters to the transverse tubule (T-tubule) membranes, which have particularly high cholesterol levels. We investigated whether T-tubule cholesterol content affects insulin-induced glucose...

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Main Authors: Llanos, Paola (Author) , Contreras-Ferrat, Ariel (Author) , Georgiev, Tihomir (Author) , Osorio-Fuentealba, Cesar (Author) , Espinosa, Alejandra (Author) , Hidalgo, Jorge (Author) , Hidalgo, Cecilia (Author) , Jaimovich, Enrique (Author)
Format: Article (Journal)
Language:English
Published: 15 February 2015
In: American journal of physiology. Endocrinology and metabolism
Year: 2015, Volume: 308, Issue: 4, Pages: E294-E305
ISSN:1522-1555
DOI:10.1152/ajpendo.00189.2014
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpendo.00189.2014
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpendo.00189.2014
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Author Notes:Paola Llanos, Ariel Contreras-Ferrat, Tihomir Georgiev, Cesar Osorio-Fuentealba, Alejandra Espinosa, Jorge Hidalgo, Cecilia Hidalgo, and Enrique Jaimovich
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Summary:Insulin stimulates glucose uptake in adult skeletal muscle by promoting the translocation of GLUT4 glucose transporters to the transverse tubule (T-tubule) membranes, which have particularly high cholesterol levels. We investigated whether T-tubule cholesterol content affects insulin-induced glucose transport.
Item Description:Gesehen am 29.06.2020
Physical Description:Online Resource
ISSN:1522-1555
DOI:10.1152/ajpendo.00189.2014

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