The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice

Insulin stimulates glucose uptake in adult skeletal muscle by promoting the translocation of GLUT4 glucose transporters to the transverse tubule (T-tubule) membranes, which have particularly high cholesterol levels. We investigated whether T-tubule cholesterol content affects insulin-induced glucose...

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Hauptverfasser: Llanos, Paola (VerfasserIn) , Contreras-Ferrat, Ariel (VerfasserIn) , Georgiev, Tihomir (VerfasserIn) , Osorio-Fuentealba, Cesar (VerfasserIn) , Espinosa, Alejandra (VerfasserIn) , Hidalgo, Jorge (VerfasserIn) , Hidalgo, Cecilia (VerfasserIn) , Jaimovich, Enrique (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 February 2015
In: American journal of physiology. Endocrinology and metabolism
Year: 2015, Jahrgang: 308, Heft: 4, Pages: E294-E305
ISSN:1522-1555
DOI:10.1152/ajpendo.00189.2014
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpendo.00189.2014
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpendo.00189.2014
Volltext
Verfasserangaben:Paola Llanos, Ariel Contreras-Ferrat, Tihomir Georgiev, Cesar Osorio-Fuentealba, Alejandra Espinosa, Jorge Hidalgo, Cecilia Hidalgo, and Enrique Jaimovich
Beschreibung
Zusammenfassung:Insulin stimulates glucose uptake in adult skeletal muscle by promoting the translocation of GLUT4 glucose transporters to the transverse tubule (T-tubule) membranes, which have particularly high cholesterol levels. We investigated whether T-tubule cholesterol content affects insulin-induced glucose transport.
Beschreibung:Gesehen am 29.06.2020
Beschreibung:Online Resource
ISSN:1522-1555
DOI:10.1152/ajpendo.00189.2014