Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age
Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating...
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| Auteurs principaux: | , , , , , |
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| Format: | Article (Journal) |
| Langue: | anglais |
| Publié: |
06 October 2015
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| In: |
Immunity & ageing
Year: 2015, Volume: 12, Numéro: 1, Pages: 1-5 |
| ISSN: | 1742-4933 |
| DOI: | 10.1186/s12979-015-0043-y |
| Accès en ligne: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12979-015-0043-y
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| Notes sur l'auteur: | Xiaoyu Wu, Maani Hakimi, Markus Wortmann, Jian Zhang, Dittmar Böckler, Susanne Dihlmann |
| Résumé: | Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating intracellular multi-protein complexes. We thus investigated gene expression of inflammasome components in PBMC of 77 vascular patients (age 22-82) in association with age. |
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| Description: | Gesehen am 30.06.2020 |
| Description matérielle: | Online Resource |
| ISSN: | 1742-4933 |
| DOI: | 10.1186/s12979-015-0043-y |