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Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age

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Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating...

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Bibliographic Details
Main Authors: Wu, Xiaoyu (Author) , Hakimi, Maani (Author) , Wortmann, Markus (Author) , Zhang, Jian (Author) , Böckler, Dittmar (Author) , Dihlmann, Susanne (Author)
Format: Article (Journal)
Language:English
Published: 06 October 2015
In: Immunity & ageing
Year: 2015, Volume: 12, Issue: 1, Pages: 1-5
ISSN:1742-4933
DOI:10.1186/s12979-015-0043-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12979-015-0043-y
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Author Notes:Xiaoyu Wu, Maani Hakimi, Markus Wortmann, Jian Zhang, Dittmar Böckler, Susanne Dihlmann
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Summary:Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating intracellular multi-protein complexes. We thus investigated gene expression of inflammasome components in PBMC of 77 vascular patients (age 22-82) in association with age.
Item Description:Gesehen am 30.06.2020
Physical Description:Online Resource
ISSN:1742-4933
DOI:10.1186/s12979-015-0043-y

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