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Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age

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Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating...

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Hauptverfasser: Wu, Xiaoyu (VerfasserIn) , Hakimi, Maani (VerfasserIn) , Wortmann, Markus (VerfasserIn) , Zhang, Jian (VerfasserIn) , Böckler, Dittmar (VerfasserIn) , Dihlmann, Susanne (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 06 October 2015
In: Immunity & ageing
Year: 2015, Jahrgang: 12, Heft: 1, Pages: 1-5
ISSN:1742-4933
DOI:10.1186/s12979-015-0043-y
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12979-015-0043-y
Volltext
Verfasserangaben:Xiaoyu Wu, Maani Hakimi, Markus Wortmann, Jian Zhang, Dittmar Böckler, Susanne Dihlmann
Beschreibung
Zusammenfassung:Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating intracellular multi-protein complexes. We thus investigated gene expression of inflammasome components in PBMC of 77 vascular patients (age 22-82) in association with age.
Beschreibung:Gesehen am 30.06.2020
Beschreibung:Online Resource
ISSN:1742-4933
DOI:10.1186/s12979-015-0043-y

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