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Heart‐specific knockout of the mitochondrial thioredoxin reductase (Txnrd2) induces metabolic and contractile dysfunction in the aging myocardium

Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart‐specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal death. The significance of Txnrd2 in aging cardiomyocytes, howe...

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Main Authors: Kiermayer, Claudia (Author) , Northrup, Emily (Author) , Schrewe, Anja (Author) , Walch, Axel (Author) , de Angelis, Martin Hrabe (Author) , Schönsiegel, Frank (Author) , Zischka, Hans (Author) , Prehn, Cornelia (Author) , Adamski, Jerzy (Author) , Bekeredjian, Raffi (Author) , Ivandic, Boris (Author) , Kupatt, Christian (Author) , Brielmeier, Markus (Author)
Format: Article (Journal)
Language:English
Published: 21 Jul 2015
In: Journal of the American Heart Association
Year: 2015, Volume: 4, Issue: 7
ISSN:2047-9980
DOI:10.1161/JAHA.115.002153
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/JAHA.115.002153
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/JAHA.115.002153
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Author Notes:Kiermayer Claudia, Northrup Emily, Schrewe Anja, Walch Axel, de Angelis Martin Hrabe, Schoensiegel Frank, Zischka Hans, Prehn Cornelia, Adamski Jerzy, Bekeredjian Raffi, Ivandic Boris, Kupatt Christian, Brielmeier Markus
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Summary:Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart‐specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal death. The significance of Txnrd2 in aging cardiomyocytes, however, has not yet been examined.
Item Description:Gesehen am 01.07.2020
Physical Description:Online Resource
ISSN:2047-9980
DOI:10.1161/JAHA.115.002153

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