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A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation

The metabolic enzyme GAPDH exhibits oxidative inactivation in response to H2O2. A proton relay system was identified that enhances H2O2 sensitivity of GAPDH distinct from its catalytic activity, which ensures viability under oxidative stress.

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Bibliographic Details
Main Authors: Peralta, David (Author) , Bronowska, Agnieszka K. (Author) , Morgan, Bruce (Author) , Dóka, Éva (Author) , Van Laer, Koen (Author) , Nagy, Péter (Author) , Gräter, Frauke (Author) , Dick, Tobias P. (Author)
Format: Article (Journal)
Language:English
Published: 12 January 2015
In: Nature chemical biology
Year: 2015, Volume: 11, Issue: 2, Pages: 156-163
ISSN:1552-4469
DOI:10.1038/nchembio.1720
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nchembio.1720
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nchembio.1720
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Author Notes:David Peralta, Agnieszka K. Bronowska, Bruce Morgan, Éva Dóka, Koen Van Laer, Péter Nagy, Frauke Gräter & Tobias P. Dick
Description
Summary:The metabolic enzyme GAPDH exhibits oxidative inactivation in response to H2O2. A proton relay system was identified that enhances H2O2 sensitivity of GAPDH distinct from its catalytic activity, which ensures viability under oxidative stress.
Item Description:Im Titel ist die Zahl 2 tiefgestellt
Gesehen am 01.07.2020
Physical Description:Online Resource
ISSN:1552-4469
DOI:10.1038/nchembio.1720

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