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Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors

Introduction: Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of A beta misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD. Methods: Within a community-based co...

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Main Authors: Stocker, Hannah (Author) , Nabers, Andreas (Author) , Perna, Laura (Author) , Möllers, Tobias (Author) , Rujescu, Dan (Author) , Hartmann, Annette (Author) , Holleczek, Bernd (Author) , Schöttker, Ben (Author) , Gerwert, Klaus (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 6 January 2020
In: Alzheimer's and dementia
Year: 2020, Volume: 16, Issue: 2, Pages: 283-291
ISSN:1552-5279
DOI:10.1016/j.jalz.2019.08.189
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jalz.2019.08.189
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Author Notes:Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette Hartmann, Bernd Holleczek, Ben Schöttker, Klaus Gerwert, Hermann Brenner
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Summary:Introduction: Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of A beta misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD. Methods: Within a community-based cohort, A beta misfolding in plasma measured by immuno-infrared sensor and APOE genotypewere determined at baseline in 770 participants followed over 14 years. Associations between A beta misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed. Results: A beta misfolding was associated with a 23-fold increased odds of clinical AD diagnosis within 14 years. No association was observed with vascular dementia/mixed dementia diagnoses. APOE4-positive participants had a 2.4-fold increased odds of clinical AD diagnosis within 14 years. Discussion: A beta misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD evenmany years before diagnosis in a community-based setting.
Item Description:Gesehen am 07.07.2020
Physical Description:Online Resource
ISSN:1552-5279
DOI:10.1016/j.jalz.2019.08.189

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