Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors
Introduction: Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of A beta misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD. Methods: Within a community-based co...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 January 2020
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| In: |
Alzheimer's and dementia
Year: 2020, Jahrgang: 16, Heft: 2, Pages: 283-291 |
| ISSN: | 1552-5279 |
| DOI: | 10.1016/j.jalz.2019.08.189 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jalz.2019.08.189
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| Verfasserangaben: | Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette Hartmann, Bernd Holleczek, Ben Schöttker, Klaus Gerwert, Hermann Brenner |
MARC
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| 245 | 1 | 0 | |a Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors |c Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette Hartmann, Bernd Holleczek, Ben Schöttker, Klaus Gerwert, Hermann Brenner |
| 246 | 3 | 3 | |a Prediction of Alzheimer's disease diagnosis within 14 years through A beta misfolding in blood plasma compared to APOE4 status, and other risk factors |
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| 520 | |a Introduction: Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of A beta misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD. Methods: Within a community-based cohort, A beta misfolding in plasma measured by immuno-infrared sensor and APOE genotypewere determined at baseline in 770 participants followed over 14 years. Associations between A beta misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed. Results: A beta misfolding was associated with a 23-fold increased odds of clinical AD diagnosis within 14 years. No association was observed with vascular dementia/mixed dementia diagnoses. APOE4-positive participants had a 2.4-fold increased odds of clinical AD diagnosis within 14 years. Discussion: A beta misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD evenmany years before diagnosis in a community-based setting. | ||
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| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a Amyloid beta (A beta) | |
| 650 | 4 | |a Amyloid-beta | |
| 650 | 4 | |a Apolipoprotein E (APOE) | |
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| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Blood plasma | |
| 650 | 4 | |a Cerebrospinal-fluid | |
| 650 | 4 | |a Cognitive impairment | |
| 650 | 4 | |a Dementia | |
| 650 | 4 | |a Infrared-sensor | |
| 650 | 4 | |a National institute | |
| 650 | 4 | |a Research framework | |
| 650 | 4 | |a Risk stratification | |
| 650 | 4 | |a Secondary structure | |
| 650 | 4 | |a Vascular dementia | |
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