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KIT mutation and loss of 14q may be sufficient for the development of clinically symptomatic very low-risk GIST

The aim of this study was to determine the minimal set of genetic alterations required for the development of a very low risk clinically symptomatic gastro-intestinal stromal tumour within the stomach wall. We studied the genome of a very low-risk gastric gastro-intestinal stromal tumour by whole-ge...

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Main Authors: Klinke, Olaf (Author) , Mizani, Tuba (Author) , Baldwin, Gouri (Author) , Bancel, Brigitte (Author) , Devouassoux-Shisheboran, Mojgan (Author) , Scoazec, Jean-Yves (Author) , Bringuier, Pierre-Paul (Author) , Feederle, Regina (Author) , Jauch, Anna (Author) , Hinderhofer, Katrin (Author) , Taniere, Philippe (Author) , Delecluse, Henri-Jacques (Author)
Format: Article (Journal)
Language:English
Published: June 23, 2015
In: PLOS ONE
Year: 2015, Volume: 10, Issue: 6
ISSN:1932-6203
DOI:10.1371/journal.pone.0130149
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0130149
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130149
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Author Notes:Olaf Karl Klinke, Tuba Mizani, Gouri Baldwin, Brigitte Bancel, Mojgan Devouassoux-Shisheboran, Jean-Yves Scoazec, Pierre-Paul Bringuier, Regina Feederle, Anna Jauch, Katrin Hinderhofer, Philippe Taniere, Henri-Jacques Delecluse
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Summary:The aim of this study was to determine the minimal set of genetic alterations required for the development of a very low risk clinically symptomatic gastro-intestinal stromal tumour within the stomach wall. We studied the genome of a very low-risk gastric gastro-intestinal stromal tumour by whole-genome sequencing, comparative genomic hybridisation and methylation profiling.
Item Description:Gesehen am 08.07.2020
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0130149

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