KIT mutation and loss of 14q may be sufficient for the development of clinically symptomatic very low-risk GIST

The aim of this study was to determine the minimal set of genetic alterations required for the development of a very low risk clinically symptomatic gastro-intestinal stromal tumour within the stomach wall. We studied the genome of a very low-risk gastric gastro-intestinal stromal tumour by whole-ge...

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Hauptverfasser: Klinke, Olaf (VerfasserIn) , Mizani, Tuba (VerfasserIn) , Baldwin, Gouri (VerfasserIn) , Bancel, Brigitte (VerfasserIn) , Devouassoux-Shisheboran, Mojgan (VerfasserIn) , Scoazec, Jean-Yves (VerfasserIn) , Bringuier, Pierre-Paul (VerfasserIn) , Feederle, Regina (VerfasserIn) , Jauch, Anna (VerfasserIn) , Hinderhofer, Katrin (VerfasserIn) , Taniere, Philippe (VerfasserIn) , Delecluse, Henri-Jacques (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 23, 2015
In: PLOS ONE
Year: 2015, Jahrgang: 10, Heft: 6
ISSN:1932-6203
DOI:10.1371/journal.pone.0130149
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0130149
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130149
Volltext
Verfasserangaben:Olaf Karl Klinke, Tuba Mizani, Gouri Baldwin, Brigitte Bancel, Mojgan Devouassoux-Shisheboran, Jean-Yves Scoazec, Pierre-Paul Bringuier, Regina Feederle, Anna Jauch, Katrin Hinderhofer, Philippe Taniere, Henri-Jacques Delecluse
Beschreibung
Zusammenfassung:The aim of this study was to determine the minimal set of genetic alterations required for the development of a very low risk clinically symptomatic gastro-intestinal stromal tumour within the stomach wall. We studied the genome of a very low-risk gastric gastro-intestinal stromal tumour by whole-genome sequencing, comparative genomic hybridisation and methylation profiling.
Beschreibung:Gesehen am 08.07.2020
Beschreibung:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0130149