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Saturation-Recovery Myocardial T 1 -Mapping during Systole: Accurate and Robust Quantification in the Presence of Arrhythmia

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Myocardial T1-mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate...

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Main Authors: Meßner, Nadja (Author) , Budjan, Johannes (Author) , Loßnitzer, Dirk (Author) , Papavassiliu, Theano (Author) , Schad, Lothar R. (Author) , Zöllner, Frank G. (Author)
Format: Article (Journal)
Language:English
Published: 27 March 2018
In: Scientific reports
Year: 2018, Volume: 8
ISSN:2045-2322
DOI:10.1038/s41598-018-23506-z
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41598-018-23506-z
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41598-018-23506-z
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Author Notes:Nadja M. Meßner, Johannes Budjan, Dirk Loßnitzer, Theano Papavassiliu, Lothar R. Schad, Sebastian Weingärtner and Frank G. Zöllner
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Summary:Myocardial T1-mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate variability, we introduce a systolic saturation-recovery T1-mapping method. The Saturation-Pulse Prepared Heart-rate independent Inversion-Recovery (SAPPHIRE) T1-mapping method was modified to enable imaging during systole. Phantom measurements were used to evaluate the insensitivity of systolic T1-mapping towards heart-rate variability. In-vivo feasibility and accuracy were demonstrated in ten healthy volunteers with native and post-contrast T1-mappping during systole and diastole. To show benefits in the presence of RR-variability, six arrhythmic patients underwent native T1-mapping. Resulting systolic SAPPHIRE T1-values showed no dependence on arrhythmia in phantom (CoV < 1%). In-vivo, significantly lower T1 (1563 ± 56 ms, precision: 84.8 ms) and ECV-values (0.20 ± 0.03) than during diastole (T1 = 1580 ± 62 ms, p = 0.0124; precision: 60.2 ms, p = 0.03; ECV = 0.21 ± 0.03, p = 0.0098) were measured, with a strong correlation of systolic and diastolic T1 (r = 0.89). In patients, mis-triggering-induced motion caused significant imaging artifacts in diastolic T1-maps, whereas systolic T1-maps displayed resilience to arrythmia. In conclusion, the proposed method enables saturation-recovery T1-mapping during systole, providing increased robustness against partial-voluming compared to diastolic imaging, for the benefit of T1-measurements in arrhythmic patients.
Item Description:Gesehen am 09.07.2020
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-018-23506-z

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