The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients: experiences at a single institution
Purpose - To investigate the hazard function of tumor recurrence in patients with completely (R0) resected non-small cell lung cancer. - Methods - A total of 1374 patients treated between 2003 and 2009 with complete resection and systematic lymph node dissection were studied. The risk of recurrence...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 September 2015
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| In: |
Lung cancer
Year: 2015, Volume: 90, Issue: 2, Pages: 224-229 |
| ISSN: | 1872-8332 |
| DOI: | 10.1016/j.lungcan.2015.09.010 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.lungcan.2015.09.010 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0169500215300544 
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| Author Notes: | Yoshikane Yamauchi, Thomas Muley, Seyer Safi, Stefan Rieken, Helge Bischoff, Jutta Kappes, Arne Warth, Felix J. F. Herth, Hendrik Dienemann, Hans Hoffmann |
| Summary: | Purpose - To investigate the hazard function of tumor recurrence in patients with completely (R0) resected non-small cell lung cancer. - Methods - A total of 1374 patients treated between 2003 and 2009 with complete resection and systematic lymph node dissection were studied. The risk of recurrence at a given time after operation was studied utilizing the cause-specific hazard function. Recurrence was categorized as local recurrence or distant recurrence. The risk distribution was assessed using clinical and pathological factors. - Results - The hazard function for recurrence presented an early peak at approximately 10 months after surgery and maintained a tapered plateau-like tail extending up to 8 years. A similar risk pattern was detected for both local recurrence and distant recurrence, while the risk of distant recurrence was higher than that of local recurrence. The double-peaked pattern of hazard rate was present in several subgroups, such as p-stage IA patients. A comparison of histology and status of nodal involvement showed that pN1-2 adenocarcinoma patients demonstrated a high hazard rate of distant recurrence and that pN0 adenocarcinoma patients exhibited a small recurrent risk for a longer time. Squamous cell carcinoma patients showed only little difference in risk. - Conclusions - The data may be useful to select patients at high risk of recurrence and may provide information for each patient to decide how to manage the postoperative follow-up individually. |
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| Item Description: | Gesehen am 09.07.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1872-8332 |
| DOI: | 10.1016/j.lungcan.2015.09.010 |