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Evaluation of cyclosporine a as a cardio- and neuroprotective agent after cardiopulmonary resuscitation in a rat model

The immunosuppressant drug cyclosporine A (CsA) is a direct inhibitor of the mitochondrial permeability transition pore, which is the common end point of many pathways of ischemic preconditioning and postconditioning. We studied the neuroprotective and cardioprotective effect of CsA after cardiac ar...

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Bibliographic Details
Main Authors: Knapp, Jürgen (Author) , Roewer, Joachim (Author) , Bruckner, Thomas (Author) , Böttiger, Bernd W. (Author) , Popp, Erik (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Shock
Year: 2015, Volume: 43, Issue: 6, Pages: 576-581
ISSN:1540-0514
DOI:10.1097/SHK.0000000000000357
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/SHK.0000000000000357
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/shockjournal/Fulltext/2015/06000/Evaluation_of_Cyclosporine_a_as_a_Cardio__and.9.aspx
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Author Notes:Jürgen Knapp, Joachim Roewer, Thomas Bruckner, Bernd W. Böttiger, and Erik Popp
Description
Summary:The immunosuppressant drug cyclosporine A (CsA) is a direct inhibitor of the mitochondrial permeability transition pore, which is the common end point of many pathways of ischemic preconditioning and postconditioning. We studied the neuroprotective and cardioprotective effect of CsA after cardiac arrest (CA) in a rat model of cardiopulmonary resuscitation.
Item Description:Gesehen am 10.07.2020
Physical Description:Online Resource
ISSN:1540-0514
DOI:10.1097/SHK.0000000000000357

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