Evaluation of cyclosporine a as a cardio- and neuroprotective agent after cardiopulmonary resuscitation in a rat model
The immunosuppressant drug cyclosporine A (CsA) is a direct inhibitor of the mitochondrial permeability transition pore, which is the common end point of many pathways of ischemic preconditioning and postconditioning. We studied the neuroprotective and cardioprotective effect of CsA after cardiac ar...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| In: |
Shock
Year: 2015, Jahrgang: 43, Heft: 6, Pages: 576-581 |
| ISSN: | 1540-0514 |
| DOI: | 10.1097/SHK.0000000000000357 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/SHK.0000000000000357 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/shockjournal/Fulltext/2015/06000/Evaluation_of_Cyclosporine_a_as_a_Cardio__and.9.aspx |
| Verfasserangaben: | Jürgen Knapp, Joachim Roewer, Thomas Bruckner, Bernd W. Böttiger, and Erik Popp |
| Zusammenfassung: | The immunosuppressant drug cyclosporine A (CsA) is a direct inhibitor of the mitochondrial permeability transition pore, which is the common end point of many pathways of ischemic preconditioning and postconditioning. We studied the neuroprotective and cardioprotective effect of CsA after cardiac arrest (CA) in a rat model of cardiopulmonary resuscitation. |
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| Beschreibung: | Gesehen am 10.07.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1540-0514 |
| DOI: | 10.1097/SHK.0000000000000357 |