Unravelling spinal circuits of pain and mechanical allodynia
How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to ca...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 August 2015
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| In: |
Neuron
Year: 2015, Volume: 87, Issue: 4, Pages: 673-675 |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2015.08.013 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuron.2015.08.013 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0896627315006881 
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| Author Notes: | Vijayan Gangadharan and Rohini Kuner |
| Summary: | How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underlying mechanical allodynia. |
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| Item Description: | Gesehen am 10.07.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2015.08.013 |