Cover Image

Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

Show other versions (1)

Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unnecessary organelles or misfolded proteins and subsequently degrade them in vesicular struct...

Full description

Saved in:
Bibliographic Details
Main Authors: Köhler, Bruno Christian (Author) , Jassowicz, Adam (Author) , Scherr, Anna-Lena (Author) , Lorenz, Stephan (Author) , Radhakrishnan, Praveen (Author) , Kautz, Nicole (Author) , Elßner, Christin (Author) , Weiß, Johanna (Author) , Jäger, Dirk (Author) , Schneider, Martin (Author) , Schulze-Bergkamen, Henning (Author)
Format: Article (Journal)
Language:English
Published: 19 November 2015
In: BMC cancer
Year: 2015, Volume: 15, Issue: 1
ISSN:1471-2407
DOI:10.1186/s12885-015-1929-y
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12885-015-1929-y
Verlag, lizenzpflichtig, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1929-y
Get full text
Author Notes:Bruno Christian Koehler, Adam Jassowicz, Anna-Lena Scherr, Stephan Lorenz, Praveen Radhakrishnan, Nicole Kautz, Christin Elssner, Johanna Weiss, Dirk Jaeger, Martin Schneider and Henning Schulze-Bergkamen
Description
Summary:Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unnecessary organelles or misfolded proteins and subsequently degrade them in vesicular structures in order to refuel cells with energy. Dysregulation of the complex autophagy signaling network has been shown to contribute to the onset and progression of cancer in various models. The Bcl-2 family of proteins comprises central regulators of apoptosis signaling and has been linked to processes involved in autophagy. The antiapoptotic members of the Bcl-2 family of proteins have been identified as promising anticancer drug targets and small molecules inhibiting those proteins are in clinical trials.
Item Description:Gesehen am 14.07.2020
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-015-1929-y

Similar Items