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Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

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Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unnecessary organelles or misfolded proteins and subsequently degrade them in vesicular struct...

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Main Authors: Köhler, Bruno Christian (Author) , Jassowicz, Adam (Author) , Scherr, Anna-Lena (Author) , Lorenz, Stephan (Author) , Radhakrishnan, Praveen (Author) , Kautz, Nicole (Author) , Elßner, Christin (Author) , Weiß, Johanna (Author) , Jäger, Dirk (Author) , Schneider, Martin (Author) , Schulze-Bergkamen, Henning (Author)
Format: Article (Journal)
Language:English
Published: 19 November 2015
In: BMC cancer
Year: 2015, Volume: 15, Issue: 1
ISSN:1471-2407
DOI:10.1186/s12885-015-1929-y
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12885-015-1929-y
Verlag, lizenzpflichtig, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1929-y
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Author Notes:Bruno Christian Koehler, Adam Jassowicz, Anna-Lena Scherr, Stephan Lorenz, Praveen Radhakrishnan, Nicole Kautz, Christin Elssner, Johanna Weiss, Dirk Jaeger, Martin Schneider and Henning Schulze-Bergkamen
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Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling by Köhler, Bruno Christian (Author) , Jassowicz, Adam (Author) , Scherr, Anna-Lena (Author) , Lorenz, Stephan (Author) , Radhakrishnan, Praveen (Author) , Kautz, Nicole (Author) , Elßner, Christin (Author) , Weiß, Johanna (Author) , Jäger, Dirk (Author) , Schneider, Martin (Author) , Schulze-Bergkamen, Henning (Author) ,

Biomed Central 2015

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