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In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography

Transthyretin familial amyloid polyneuropathy is a rare, autosomal-dominant inherited multisystem disorder usually manifesting with a rapidly progressive, axonal, distally-symmetric polyneuropathy. The detection of nerve injury by nerve conduction studies is limited, due to preferential involvement...

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Main Authors: Hayes, Jennifer (Author) , Hund, Ernst (Author) , Hornung, Benjamin (Author) , Hegenbart, Ute (Author) , Schönland, Stefan (Author) , Kimmich, Christoph (Author) , Kristen, Arnt (Author) , Purrucker, Jan (Author) , Röcken, Christoph (Author) , Heiland, Sabine (Author) , Bendszus, Martin (Author) , Pham, Mirko (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Brain
Year: 2014, Volume: 138, Issue: 3, Pages: 549-562
ISSN:1460-2156
DOI:10.1093/brain/awu344
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/brain/awu344
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/brain/article/138/3/549/332291
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Author Notes:Jennifer Kollmer, Ernst Hund, Benjamin Hornung, Ute Hegenbart, Stefan O. Schönland, Christoph Kimmich, Arnt V. Kristen, Jan Purrucker, Christoph Röcken, Sabine Heiland, Martin Bendszus and Mirko Pham
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Summary:Transthyretin familial amyloid polyneuropathy is a rare, autosomal-dominant inherited multisystem disorder usually manifesting with a rapidly progressive, axonal, distally-symmetric polyneuropathy. The detection of nerve injury by nerve conduction studies is limited, due to preferential involvement of small-fibres in early stages. We investigated whether lower limb nerve-injury can be detected, localized and quantified in vivo by high-resolution magnetic resonance neurography.
Item Description:Advance access publication December 19, 2014
Gesehen am 15.07.2020
Physical Description:Online Resource
ISSN:1460-2156
DOI:10.1093/brain/awu344

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