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Frailty and telomere length: cross-sectional analysis in 3537 older adults from the ESTHER cohort

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Both telomere length and frailty were observed to be associated with aging. Whether and to what extent telomere length is related to frailty is essentially unknown. In this cross-sectional analysis of baseline data of 3537 community-dwelling adults aged 50 to 75years of a large German cohort study,...

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Main Authors: Saum, Kai-Uwe (Author) , Dieffenbach, Aida Karina (Author) , Müezzinler, Aysel (Author) , Müller, Heiko (Author) , Holleczek, Bernd (Author) , Stegmaier, Christa (Author) , Butterbach, Katja (Author) , Schick, Matthias (Author) , Canzian, Federico (Author) , Stammer, Hermann (Author) , Boukamp, Petra (Author) , Hauer, Klaus (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 21 August 2014
In: Experimental gerontology
Year: 2014, Volume: 58, Pages: 250-255
ISSN:1873-6815
DOI:10.1016/j.exger.2014.08.009
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.exger.2014.08.009
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0531556514002459
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Author Notes:Kai-Uwe Saum, Aida Karina Dieffenbach, Aysel Müezzinler, Heiko Müller, Bernd Holleczek, Christa Stegmaier, Katja Butterbach, Matthias Schick, Federico Canzian, Hermann Stammer, Petra Boukamp, Klaus Hauer, Hermann Brenner
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Summary:Both telomere length and frailty were observed to be associated with aging. Whether and to what extent telomere length is related to frailty is essentially unknown. In this cross-sectional analysis of baseline data of 3537 community-dwelling adults aged 50 to 75years of a large German cohort study, we assessed the hypothesis that shorter telomere length might be a biological marker for frailty. Using whole blood DNA we examined mean telomere repeat copy to single gene copy number (T/S ratio) using quantitative PCR. Construction of a frailty index (FI) was based on a deficit accumulation approach, which quantifies frailty as ratio of the deficits present divided by the total number of deficits considered. Mean FI was determined according to age by tertiles of T/S ratio. Furthermore, we used correlation analyses stratified for gender and age groups to examine the association of the T/S ratio with frailty. Mean FI value was similar across tertiles of the T/S ratio (0.24±0.14, 0.24±0.14 and 0.23±0.14, respectively (p=0.09)), and FI and the T/S ratio were uncorrelated in gender- and age-specific analyses. In conclusion, T/S ratio and frailty were unrelated in this large sample of older adults. T/S ratio may therefore not be a meaningful biological marker for frailty.
Item Description:Gesehen am 15.07.2020
Physical Description:Online Resource
ISSN:1873-6815
DOI:10.1016/j.exger.2014.08.009

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