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Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma

Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed...

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Main Authors: Kong, Bo (Author) , Cheng, Tao (Author) , Qian, Chengjia (Author) , Wu, Weiwei (Author) , Steiger, Katja (Author) , Cao, Jing (Author) , Schlitter, Anna Melissa (Author) , Regel, Ivonne (Author) , Raulefs, Susanne (Author) , Friess, Helmut (Author) , Erkan, Mert (Author) , Esposito, Irene (Author) , Kleeff, Jörg H. (Author) , Michalski, Christoph (Author)
Format: Article (Journal)
Language:English
Published: 18 December 2015
In: Molecular cancer
Year: 2015, Volume: 14, Issue: 1
ISSN:1476-4598
DOI:10.1186/s12943-015-0483-1
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12943-015-0483-1
Verlag, lizenzpflichtig, Volltext: https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-015-0483-1
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Author Notes:Bo Kong, Tao Cheng, Chengjia Qian, Weiwei Wu, Katja Steiger, Jing Cao, Anna Melissa Schlitter, Ivonne Regel, Susanne Raulefs, Helmut Friess, Mert Erkan, Irene Esposito, Jörg Kleeff and Christoph W. Michalski
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Summary:Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyzing whether activation of mTOR with a concomitant loss of p53 may initiate ACC.
Item Description:Gesehen am 15.07.2020
Physical Description:Online Resource
ISSN:1476-4598
DOI:10.1186/s12943-015-0483-1

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