Intraindividual right-left comparison of sonographic features in polycystic ovary syndrome (PCOS) diagnosis
Objective - Sonographic features of polycystic ovaries consist of elevated antral follicle count or ovarian volume of at least one ovary. The aim of this prospective cross-sectional study was to estimate intraindividual differences in sonographic measurements between the both ovaries of PCOS patient...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 August 2014
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| In: |
European journal of obstetrics & gynecology and reproductive biology
Year: 2014, Volume: 181, Pages: 124-129 |
| ISSN: | 1872-7654 |
| DOI: | 10.1016/j.ejogrb.2014.07.029 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejogrb.2014.07.029 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0301211514004011 
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| Author Notes: | Angela Köninger, Laura Koch, Philippos Edimiris, Stefanie Nießen, Sabine Kasimir-Bauer, Rainer Kimmig, Thomas Strowitzki, Börge Schmidt |
| Summary: | Objective - Sonographic features of polycystic ovaries consist of elevated antral follicle count or ovarian volume of at least one ovary. The aim of this prospective cross-sectional study was to estimate intraindividual differences in sonographic measurements between the both ovaries of PCOS patients and controls and clinical consequences. - Study design - Both ovaries of 85 PCOS patients and 48 controls were scanned transvaginally and agreement of sonographic measurements was analyzed using the Bland-Altman method. Concordance correlation coefficients (CCC) were computed. - Results - Mean differences between right and left ovaries were 0.24 (95% confidence interval [95% CI]: −0.32-0.80) follicles for AFC and 1.14 (95% CI: 0.34-1.92)ml for OV in the whole study population, 0.14 (95% CI: −0.68-0.96) follicles for AFC and 1.48 (95% CI: 0.39-2.58)ml for OV in PCOS patients, 0.42 (95% CI: −0.19-1.02) follicles for AFC and 0.53 (95% CI: −0.50-1.56)ml for OV in controls. Rather wide limits of agreement and low CCCs (<0.7 for all estimates) indicated poor agreement between the ovaries for both sonographic measurements. Width between lower and upper limits of agreement was higher for PCOS patients than for controls. 23.5% of the PCOS patients showed polycystic ovarian morphology (PCOM) only in one ovary, resulting in 9.4% potentially missed PCOS diagnosis according to the Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. - Conclusion - Substantial differences in antral follicle count and ovarian volume between the right and left ovary were observed. In approximately 10% of the PCOS patients in our study only the examination of both ovaries has led to a reliable diagnosis of PCOS. In clinical practice it is recommended to scan both ovaries for a reliable diagnosis of abnormal sonographic findings in PCOM and PCOS diagnosis. |
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| Item Description: | Gesehen am 15.07.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7654 |
| DOI: | 10.1016/j.ejogrb.2014.07.029 |