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Current use of metformin in addition to insulin in pediatric patients with type 1 diabetes mellitus: an analysis based on a large diabetes registry in Germany and Austria

With increasing obesity in childhood and adolescence, weight gain, and insulin resistance become also more frequent in patients with type 1 diabetes mellitus (T1DM). Especially during puberty, insulin therapy often has to be intensified and higher insulin doses are necessary. Some studies point to a...

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Main Authors: Konrad, Katja (Author) , Datz, Nicolin (Author) , Engelsberger, Ilse (Author) , Grulich-Henn, Jürgen (Author) , Hoertenhuber, Thomas (Author) , Knauth, Burkhild (Author) , Meissner, Thomas (Author) , Wiegand, Susanna (Author) , Woelfle, Joachim (Author) , Holl, Reinhard W. (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Pediatric diabetes
Year: 2014, Volume: 16, Issue: 7, Pages: 529-537
ISSN:1399-5448
DOI:10.1111/pedi.12203
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1111/pedi.12203
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12203
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Author Notes:Katja Konrad, Nicolin Datz, Ilse Engelsberger, Jürgen Grulich‐Henn, Thomas Hoertenhuber, Burkhild Knauth, Thomas Meissner, Susanna Wiegand, Joachim Woelfle, Reinhard W. Holl
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Summary:With increasing obesity in childhood and adolescence, weight gain, and insulin resistance become also more frequent in patients with type 1 diabetes mellitus (T1DM). Especially during puberty, insulin therapy often has to be intensified and higher insulin doses are necessary. Some studies point to a beneficial effect of metformin in addition to insulin in these patients. In order to describe current practice and possible benefits, we compared pediatric T1DM patients with insulin plus metformin (n = 525) to patients with insulin therapy only (n = 57 487) in a prospective multicenter analysis.
Item Description:First published: 18 August 2014
Gesehen am 17.07.2020
Physical Description:Online Resource
ISSN:1399-5448
DOI:10.1111/pedi.12203

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