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Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP

Adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis. Experience with allo-SCT for ATL appears encouraging but is limited to Japanese series. This retrospective analysis of the EBMT registry revealed 21 HTLV-I seropositive ATL including 7 acute and 12 lymphoma subtypes. Four patients rece...

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Main Authors: Bazarbachi, Ali (Author) , Cwynarski, K. (Author) , Boumendil, A. (Author) , Finel, H. (Author) , Fields, P. (Author) , Raj, K. (Author) , Nagler, A. (Author) , Mohty, M. (Author) , Sureda, A. (Author) , Dreger, Peter (Author) , Hermine, O. (Author)
Format: Article (Journal)
Language:English
Published: 14 July 2014
In: Bone marrow transplantation
Year: 2014, Volume: 49, Issue: 10, Pages: 1266-1268
ISSN:1476-5365
DOI:10.1038/bmt.2014.143
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bmt.2014.143
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bmt2014143
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Author Notes:A. Bazarbachi, K. Cwynarski, A. Boumendil, H. Finel, P. Fields, K. Raj, A. Nagler, M. Mohty, A. Sureda, P. Dreger and O. Hermine
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Summary:Adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis. Experience with allo-SCT for ATL appears encouraging but is limited to Japanese series. This retrospective analysis of the EBMT registry revealed 21 HTLV-I seropositive ATL including 7 acute and 12 lymphoma subtypes. Four patients received auto-SCT and rapidly died from ATL. Out of 17 allo-SCT (4 myeloablative, 13 reduced intensity), 6 are still alive (4 were in CR1 at SCT). Eleven patients died within 2 years, eight from relapse/progression and three from transplant toxicity. Six of seven informative patients who lived >12 months had chronic GVHD. Overall these results indicate that allo-SCT but not auto-SCT may salvage a subset of ATL patients, supporting the existence of graft vs ATL effect also in non-Japanese patients.
Item Description:Gesehen am 17.07.2020
Physical Description:Online Resource
ISSN:1476-5365
DOI:10.1038/bmt.2014.143

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