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Normal mast cell numbers in the tissues of AhR-deficient mice

The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development...

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Main Authors: Pilz, Caroline (Author) , Feyerabend, Thorsten B. (Author) , Sonner, Jana (Author) , Redaelli, Chiara (Author) , Peter, Katharina (Author) , Kunze, Anja (Author) , Haas, Katharina (Author) , Esser, Charlotte (Author) , Schäkel, Knut (Author) , Wick, Wolfgang (Author) , Rodewald, Hans-Reimer (Author) , Lanz, Tobias (Author) , Platten, Michael (Author)
Format: Article (Journal) Editorial
Language:English
Published: 2016
In: Experimental dermatology
Year: 2015, Volume: 25, Issue: 1, Pages: 62-63
ISSN:1600-0625
DOI:10.1111/exd.12864
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/exd.12864
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.12864
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Author Notes:Caroline Pilz, Thorsten Feyerabend, Jana Sonner, Chiara Redaelli, Katharina Peter, Anja Kunze, Katharina Haas, Charlotte Esser, Knut Schäkel, Wolfgang Wick, Hans-Reimer Rodewald, Tobias V. Lanz and Michael Platten
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Summary:The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development and maintenance in skin, peritoneal exudate cells (PECs) and lymph nodes, we studied in depth their phenotype in AhR-deficient mice. Our findings do not provide any evidence for a suspected role of the AhR in mast cell homeostasis.
Item Description:First published: 07 October 2015
Gesehen am 20.07.2020
Physical Description:Online Resource
ISSN:1600-0625
DOI:10.1111/exd.12864

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