Reference values for left and right ventricular trabeculation and non-compacted myocardium
Background - Since the differentiation between physiological and pathological trabeculation is challenging, we assessed its distribution in a reference population of selected healthy volunteers. - Methods - We studied 117 subjects (58 males) stratified into age tertiles and by gender. Cardiovascular...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 March 2015
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| In: |
International journal of cardiology
Year: 2015, Volume: 185, Pages: 240-247 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2015.03.065 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2015.03.065 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0167527315003034 
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| Author Notes: | Florian André, Astrid Burger, Dirk Loßnitzer, Sebastian J. Buss, Hassan Abdel-Aty, Evangelos Gianntisis, Henning Steen, Hugo A. Katus |
| Summary: | Background - Since the differentiation between physiological and pathological trabeculation is challenging, we assessed its distribution in a reference population of selected healthy volunteers. - Methods - We studied 117 subjects (58 males) stratified into age tertiles and by gender. Cardiovascular magnetic resonance images were acquired using a standard SSFP-sequence. Left and right ventricular (LV/RV) end-diastolic (EDV), end-systolic (ESV) and trabeculated volumes indexed to the body surface area as well as ejection fraction (EF) were quantified in short-axis views. The maximum non-compacted-to-compacted (NC/C) ratio was measured in long-axis views. - Results - The trabeculated volumes were significantly larger in men than in women and decreased with age. The correlation between both was moderate (r=0.46; p<0.001). LV trabeculated volume was positively associated with EDV and ESV (r=0.74; r=0.59; both p<0.001) and negatively with EF (r=−0.27; p<0.005). It was no independent predictor for EF. The maximum NC/C ratio was >2.3 in 46.2% and >2.5 in 37.6% of the subjects, which is regarded as abnormal in current literature. The fraction of subjects with a maximum NC/C ratio >2.3 and the mean maximum NC/C ratio differed significantly between gender but not between age groups. An increasing NC/C ratio was associated with a significant decrease in EF (r=−0.21; p<0.05). - Conclusion - A considerable amount of healthy volunteers fulfils the current diagnostic criteria of LV noncompaction with female subjects showing a higher fraction of false-positive results than males. LV trabeculated volume is more pronounced in young subjects and declines with age. The use of age- and gender-specific reference values as provided in this study may facilitate the delineation of physiological and pathological findings. |
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| Item Description: | Der Name Gianntisis ist falsch geschrieben Gesehen am 23.07.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2015.03.065 |