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Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2

Circular chromosome conformation capture (4C) has provided important insights into three dimensional (3D) genome organization and its critical impact on the regulation of gene expression. We developed a new quantitative framework based on polymer physics for the analysis of paired-end sequencing 4C...

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Main Authors: Zepeda-Mendoza, Cinthya J. (Author) , Mukhopadhyay, Swagatam (Author) , Wong, Emily S. (Author) , Harder, Nathalie (Author) , Splinter, Erik (Author) , de Wit, Elzo (Author) , Eckersley-Maslin, Melanie A. (Author) , Ried, Thomas (Author) , Eils, Roland (Author) , Rohr, Karl (Author) , Mills, Alea (Author) , de Laat, Wouter (Author) , Flicek, Paul (Author) , Sengupta, Anirvan M. (Author) , Spector, David L. (Author)
Format: Article (Journal)
Language:English
Published: 21 November 2015
In: BMC genomics
Year: 2015, Volume: 16, Issue: 1, Pages: 1-17
ISSN:1471-2164
DOI:10.1186/s12864-015-2137-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12864-015-2137-5
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Author Notes:Cinthya J. Zepeda-Mendoza, Swagatam Mukhopadhyay, Emily S. Wong, Nathalie Harder, Erik Splinter, Elzo de Wit, Melanie A. Eckersley-Maslin, Thomas Ried, Roland Eils, Karl Rohr, Alea Mills, Wouter de Laat, Paul Flicek, Anirvan M. Sengupta & David L. Spector
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Summary:Circular chromosome conformation capture (4C) has provided important insights into three dimensional (3D) genome organization and its critical impact on the regulation of gene expression. We developed a new quantitative framework based on polymer physics for the analysis of paired-end sequencing 4C (PE-4Cseq) data. We applied this strategy to the study of chromatin interaction changes upon a 4.3 Mb DNA deletion in mouse region 4E2.
Item Description:Gesehen am 23.07.2020
Physical Description:Online Resource
ISSN:1471-2164
DOI:10.1186/s12864-015-2137-5

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