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Continuous-flow left ventricular assist device thrombosis: a danger foreseen is a danger avoided

Left ventricular assist devices (LVAD) are an increasingly implemented therapeutic intervention for patients with end-stage heart failure. A growing body of evidence, however, has shown an elevated risk of device thrombosis, a major complication jeopardizing the patient’s post-implantation survival....

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Main Authors: Fatullayev, Javid (Author) , Samak, Mostafa (Author) , Sabashnikov, Anton (Author) , Zeriouh, Mohamed (Author) , Rahmanian, Parwis B. (Author) , Choi, Yeong-Hoon (Author) , Schmack, Bastian (Author) , Kallenbach, Klaus (Author) , Ruhparwar, Arjang (Author) , Eghbalzadeh, Kaveh (Author) , Dohmen, Pascal M. (Author) , Karck, Matthias (Author) , Wippermann, Jens (Author) , Wahlers, Thorsten (Author) , Popov, Aron-Frederik (Author) , Simon, André R. (Author) , Weymann, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 2015.07.01
In: Medical science monitor. Basic research
Year: 2015, Volume: 21, Pages: 141-144
ISSN:2325-4416
DOI:10.12659/MSMBR.894840
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.12659/MSMBR.894840
Verlag, lizenzpflichtig, Volltext: https://basic.medscimonit.com/abstract/index/idArt/894840
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Author Notes:Javid Fatullayev, Mostafa Samak, Anton Sabashnikov, Mohamed Zeriouh, Parwis B. Rahmanian, Yeong-Hoon Choi, Bastian Schmack, Klaus Kallenbach, Arjang Ruhparwar, Kaveh Eghbalzadeh, Pascal M. Dohmen, Matthias Karck, Jens Wippermann, Thorsten Wahlers, Aron-Frederik Popov, Andre R. Simon, Alexander Weymann
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Summary:Left ventricular assist devices (LVAD) are an increasingly implemented therapeutic intervention for patients with end-stage heart failure. A growing body of evidence, however, has shown an elevated risk of device thrombosis, a major complication jeopardizing the patient’s post-implantation survival. To date, multiple causative factors for LVAD thrombosis have been identified, such as internal shear stress, device material, infection, and inadequate anticoagulation. - Understanding the mechanisms leading to LVAD thrombosis will not only enable device optimization, but also allow for better patient handling, hence improving post-implantation outcome. In this review we highlight the most commonly identified factors leading to LVAD thrombosis and discuss their mechanisms.
Item Description:Gesehen am 23.07.2020
Physical Description:Online Resource
ISSN:2325-4416
DOI:10.12659/MSMBR.894840

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