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Diverse intracellular pathogens activate type III interferon expression from peroxisomes

Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon–independent responses are undefined....

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Bibliographic Details
Main Authors: Odendall, Charlotte (Author) , Boulant, Steeve (Author)
Format: Article (Journal)
Language:English
Published: 22 June 2014
In: Nature immunology
Year: 2014, Volume: 15, Issue: 8, Pages: 717-726
ISSN:1529-2916
DOI:10.1038/ni.2915
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ni.2915
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ni.2915
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Author Notes:Charlotte Odendall, Evelyn Dixit, Fabrizia Stavru, Helene Bierne, Kate M. Franz, Ann Fiegen Durbin, Steeve Boulant, Lee Gehrke, Pascale Cossart & Jonathan C. Kagan
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Summary:Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon–independent responses are undefined. We found that RIG-I like receptors (RLRs) induce type III interferon expression in a variety of human cell types, and identified factors that differentially regulate expression of type I and type III interferons. We identified peroxisomes as a primary site of initiation of type III interferon expression, and revealed that the process of intestinal epithelial cell differentiation upregulates peroxisome biogenesis and promotes robust type III interferon responses in human cells. These findings highlight the importance of different intracellular organelles in specific innate immune responses.
Item Description:Gesehen am 24.07.2020
Physical Description:Online Resource
ISSN:1529-2916
DOI:10.1038/ni.2915

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