An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media
Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum’s acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally f...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 May 2014
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| In: |
Molecular diversity
Year: 2014, Volume: 18, Issue: 3, Pages: 535-543 |
| ISSN: | 1573-501X |
| DOI: | 10.1007/s11030-014-9522-x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11030-014-9522-x
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| Author Notes: | Saber Mehrparvar, Saeed Balalaie, Mahnaz Rabbanizadeh, Elmira Ghabraie, Frank Rominger |
| Summary: | Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum’s acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally friendly profile are the advantages of this method for the synthesis of 2-pyridone-3-carboxylic acid derivatives. |
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| Item Description: | Gesehen am 24.07.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1573-501X |
| DOI: | 10.1007/s11030-014-9522-x |