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Short-term effects of comprehensive pulmonary rehabilitation and its maintenance in patients with idiopathic pulmonary fibrosis: a randomized controlled trial

The recommendation for pulmonary rehabilitation (PR) in idiopathic pulmonary fibrosis (IPF) is weak with low-quality evidence. Therefore, the aim of this study is to investigate short-term PR effects and their maintenance after a 3-month follow-up. Fifty-four IPF patients were randomized into a grou...

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Main Authors: Jarosch, Inga (Author) , Schneeberger, Tessa (Author) , Gloeckl, Rainer (Author) , Kreuter, Michael (Author) , Frankenberger, Marion (Author) , Neurohr, Claus (Author) , Prasse, Antje (Author) , Freise, Julia (Author) , Behr, Juergen (Author) , Hitzl, Wolfgang (Author) , Koczulla, Andreas R. (Author) , Kenn, Klaus (Author)
Format: Article (Journal)
Language:English
Published: 21 May 2020
In: Journal of Clinical Medicine
Year: 2020, Volume: 9, Issue: 5
ISSN:2077-0383
DOI:10.3390/jcm9051567
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm9051567
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/9/5/1567
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Author Notes:Inga Jarosch, Tessa Schneeberger, Rainer Gloeckl, Michael Kreuter, Marion Frankenberger, Claus Neurohr, Antje Prasse, Julia Freise, Juergen Behr, Wolfgang Hitzl, Andreas R. Koczulla and Klaus Kenn
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Summary:The recommendation for pulmonary rehabilitation (PR) in idiopathic pulmonary fibrosis (IPF) is weak with low-quality evidence. Therefore, the aim of this study is to investigate short-term PR effects and their maintenance after a 3-month follow-up. Fifty-four IPF patients were randomized into a group receiving a 3-week comprehensive, inpatient PR (n = 34, FVC: 74 ± 19% pred.) or usual care (UC) (n = 17, FVC: 72 ± 20%pred.). Outcomes were measured at baseline (T1), after intervention (T2), and 3 months after T2 (T3). A 6-min walk distance (6MWD) was used as the primary outcome and chronic respiratory disease questionnaire (CRQ) scores as the secondary outcome. Change in 6MWD from T1 to T2 (Δ = 61 m, 95% CI (18.5–102.4), p = 0.006) but not from T1 to T3 (∆ = 26 m, 95% CI (8.0–61.5), p = 0.16) differed significantly between groups. Higher baseline FVC and higher anxiety symptoms were significant predictors of better short-term 6MWD improvements. For the change in CRQ total score, a significant between-group difference from T1 to T2 (∆ = 3.0 pts, 95% CI (0.7–5.3), p = 0.01) and from T1 to T3 (∆ = 3.5 pts, 95% CI (1.5–5.4), p = 0.001) was found in favour of the PR group. To conclude, in addition to the short-term benefits, inpatient PR is effective at inducing medium-term quality of life improvements in IPF. PR in the early stages of the disease seems to provoke the best benefits.
Item Description:Gesehen am 24.07.2020
Physical Description:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm9051567

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