Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria
Background - Patients with phenylketonuria have been reported to be deficient in long-chain polyunsaturated fatty acids (LCPUFAs). It has been postulated that good compliance with the dietary regimen negatively influences LCPUFA status. - Methods - In 36 patients with phenylketonuria and 18 age-matc...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 April 2016
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| In: |
Prostaglandins, leukotrienes and essential fatty acids
Year: 2016, Volume: 109, Pages: 52-57 |
| ISSN: | 1532-2823 |
| DOI: | 10.1016/j.plefa.2016.04.005 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.plefa.2016.04.005 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0952327816300059 
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| Author Notes: | Gwendolyn Gramer, Gisela Haege, Claus-Dieter Langhans, Vera Schuhmann, Peter Burgard, Georg F. Hoffmann |
| Summary: | Background - Patients with phenylketonuria have been reported to be deficient in long-chain polyunsaturated fatty acids (LCPUFAs). It has been postulated that good compliance with the dietary regimen negatively influences LCPUFA status. - Methods - In 36 patients with phenylketonuria and 18 age-matched healthy control subjects LCPUFA-levels in plasma phospholipids and cholesteryl esters, erythrocyte phosphatidylcholine and phosphatidylethanolamine were evaluated. - Results - Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels did not differ significantly between patients and control subjects in plasma and erythrocyte fractions. There was a significant negative correlation between SDS (standard deviation) scores of DHA-levels in erythrocyte parameters from the respective age-matched control group and patients’ concurrent and long-term phenylalanine levels for erythrocyte phosphatidylethanolamine and erythrocyte phosphatidylcholine. Patients with lower (higher) phenylalanine levels had positive (negative) DHA-SDS. - Conclusion - In contrast to previous reports we did not find lower LCPUFA-levels in patients with phenylketonuria compared to age-matched healthy control subjects. Good dietary control was associated with better LCPUFA status. |
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| Item Description: | Gesehen am 30.07.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1532-2823 |
| DOI: | 10.1016/j.plefa.2016.04.005 |