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An immobilised Grubbs 2nd generation catalyst for application in flow-through devices

An improved immobilised Grubbs 2nd generation catalyst and its application in flow-through devices, shown for on-column reaction gas chromatography (ocRGC), has been studied. The coupling of a reaction capillary and a separation column in GC/MS allows direct reaction monitoring and analysis of conve...

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Bibliographic Details
Main Authors: Gmeiner, Julia Renate (Author) , Leopold, Max (Author) , Lang, Carolin (Author) , Gaertner, Ute (Author) , Trapp, Oliver (Author)
Format: Article (Journal)
Language:English
Published: May 28, 2014
In: Advanced synthesis & catalysis
Year: 2014, Volume: 356, Issue: 9, Pages: 2081-2087
ISSN:1615-4169
DOI:10.1002/adsc.201301182
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/adsc.201301182
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.201301182
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Author Notes:Julia Gmeiner, Max Seibicke, Carolin Lang, Ute Gärtner, and Oliver Trapp
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Summary:An improved immobilised Grubbs 2nd generation catalyst and its application in flow-through devices, shown for on-column reaction gas chromatography (ocRGC), has been studied. The coupling of a reaction capillary and a separation column in GC/MS allows direct reaction monitoring and analysis of conversion as well as reaction kinetics. The presented permanently bonded N-heterocyclic carbene ligand shows a great stability and activity in ring closing metathesis reactions. A salt-free approach was used to generate the carbene ligand, which can be directly monitored by mass spectrometry. The very flexible design of the immobilised ligand system in reaction channels and capillaries of flow through systems allows the preparation of various catalysts using a broad variety of metal precursors. This strategy of immobilised catalytically active complexes offers a wide range of on-column reactions combinable with fast reaction screening by high throughput experimentation.
Item Description:Gesehen am 10.08.2020
Physical Description:Online Resource
ISSN:1615-4169
DOI:10.1002/adsc.201301182

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