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Endogenous nitric-oxide synthase inhibitor ADMA after acute brain injury

Previous results on nitric oxide (NO) metabolism after traumatic brain injury (TBI) show variations in NO availability and controversial effects of exogenous nitric oxide synthase (NOS)-inhibitors. Furthermore, elevated levels of the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) were r...

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Bibliographic Details
Main Authors: Jung, Carla Sabine (Author) , Wispel, Christian (Author) , Zweckberger, Klaus (Author) , Beynon, Christopher (Author) , Hertle, Daniel (Author) , Sakowitz, Oliver (Author) , Unterberg, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 6 March 2014
In: International journal of molecular sciences
Year: 2014, Volume: 15, Issue: 3, Pages: 4088-4103
ISSN:1422-0067
DOI:10.3390/ijms15034088
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms15034088
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/15/3/4088
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Author Notes:Carla S. Jung, Christian Wispel, Klaus Zweckberger, Christopher Beynon, Daniel Hertle, Oliver W. Sakowitz and Andreas W. Unterberg
Description
Summary:Previous results on nitric oxide (NO) metabolism after traumatic brain injury (TBI) show variations in NO availability and controversial effects of exogenous nitric oxide synthase (NOS)-inhibitors. Furthermore, elevated levels of the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) were reported in cerebro-spinal fluid (CSF) after traumatic subarachnoid hemorrhage (SAH). Therefore, we examined whether ADMA and the enzymes involved in NO- and ADMA-metabolism are expressed in brain tissue after TBI and if time-dependent changes occur. TBI was induced by controlled cortical impact injury (CCII) and neurological performance was monitored. Expression of NOS, ADMA, dimethylarginine dimethylaminohydrolases (DDAH) and protein-arginine methyltransferase 1 (PRMT1) was determined by immunostaining in different brain regions and at various time-points after CCII. ADMA and PRMT1 expression decreased in all animals after TBI compared to the control group, while DDAH1 and DDAH2 expression increased in comparison to controls. Furthermore, perilesionally ADMA is positively correlated with neuroscore performance, while DDAH1 and DDAH2 are negatively correlated. ADMA and its metabolizing enzymes show significant temporal changes after TBI and may be new targets in TBI treatment.
Item Description:Gesehen am 12.08.2020
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms15034088

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