Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging
Fluorescent Si-rhodamines were modified to enable complexation with the Re(i)- and 99mTc(i)-tricarbonyl core. The corresponding complexes exhibit suitable properties as bimodal imaging probes for SPECT- and optical imaging in vitro. Importantly, the novel in- aqueous-solution-stable, functionalized...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 14, 2020
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| In: |
Dalton transactions
Year: 2020, Volume: 49, Issue: 22, Pages: 7294-7298 |
| ISSN: | 1477-9234 |
| DOI: | 10.1039/d0dt01084g |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/d0dt01084g
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| Author Notes: | Thines Kanagasundaram, Carsten S. Kramer, Eszter Boros and Klaus Kopka |
| Summary: | Fluorescent Si-rhodamines were modified to enable complexation with the Re(i)- and 99mTc(i)-tricarbonyl core. The corresponding complexes exhibit suitable properties as bimodal imaging probes for SPECT- and optical imaging in vitro. Importantly, the novel in- aqueous-solution-stable, functionalized Si-rhodamines retain favourable optical properties after complexation (QY = 0.09, λabs = 654 nm, λem = 669 nm in PBS) and show promising near-infrared optical properties for potential in vivo applications enabling bimodal scintigraphic imaging and optical imaging, e.g. used in radio- and fluorescence-guided tumour resection. |
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| Item Description: | Gesehen am 12.08.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1477-9234 |
| DOI: | 10.1039/d0dt01084g |