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A germline mutation in the BRCA13’UTR predicts stage IV breast cancer

A germline, variant in the BRCA1 3’UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. Here, we tested the hypothesis that this variant predicts tumor biology, like other 3’UTR mu...

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Main Authors: Dorairaj, Jemima J. (Author) , Salzman, David W. (Author) , Wall, Deirdre (Author) , Rounds, Tiffany (Author) , Preskill, Carina (Author) , Sullivan, Catherine AW (Author) , Lindner, Robert (Author) , Curran, Catherine (Author) , Lezon-Geyda, Kim (Author) , McVeigh, Terri (Author) , Harris, Lyndsay (Author) , Newell, John (Author) , Kerin, Michael J. (Author) , Wood, Marie (Author) , Miller, Nicola (Author) , Weidhaas, Joanne B. (Author)
Format: Article (Journal)
Language:English
Published: 10 June 2014
In: BMC cancer
Year: 2014, Volume: 14
ISSN:1471-2407
DOI:10.1186/1471-2407-14-421
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-14-421
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Author Notes:Jemima J. Dorairaj, David W. Salzman, Deirdre Wall, Tiffany Rounds, Carina Preskill, Catherine AW Sullivan, Robert Lindner, Catherine Curran, Kim Lezon-Geyda, Terri McVeigh, Lyndsay Harris, John Newell, Michael J. Kerin, Marie Wood, Nicola Miller and Joanne B. Weidhaas
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Summary:A germline, variant in the BRCA1 3’UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. Here, we tested the hypothesis that this variant predicts tumor biology, like other 3’UTR mutations in cancer.
Item Description:Gesehen am 12.08.2020
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-14-421

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