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A germline mutation in the BRCA13’UTR predicts stage IV breast cancer

A germline, variant in the BRCA1 3’UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. Here, we tested the hypothesis that this variant predicts tumor biology, like other 3’UTR mu...

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Hauptverfasser: Dorairaj, Jemima J. (VerfasserIn) , Salzman, David W. (VerfasserIn) , Wall, Deirdre (VerfasserIn) , Rounds, Tiffany (VerfasserIn) , Preskill, Carina (VerfasserIn) , Sullivan, Catherine AW (VerfasserIn) , Lindner, Robert (VerfasserIn) , Curran, Catherine (VerfasserIn) , Lezon-Geyda, Kim (VerfasserIn) , McVeigh, Terri (VerfasserIn) , Harris, Lyndsay (VerfasserIn) , Newell, John (VerfasserIn) , Kerin, Michael J. (VerfasserIn) , Wood, Marie (VerfasserIn) , Miller, Nicola (VerfasserIn) , Weidhaas, Joanne B. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 June 2014
In: BMC cancer
Year: 2014, Jahrgang: 14
ISSN:1471-2407
DOI:10.1186/1471-2407-14-421
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-14-421
Volltext
Verfasserangaben:Jemima J. Dorairaj, David W. Salzman, Deirdre Wall, Tiffany Rounds, Carina Preskill, Catherine AW Sullivan, Robert Lindner, Catherine Curran, Kim Lezon-Geyda, Terri McVeigh, Lyndsay Harris, John Newell, Michael J. Kerin, Marie Wood, Nicola Miller and Joanne B. Weidhaas
Beschreibung
Zusammenfassung:A germline, variant in the BRCA1 3’UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. Here, we tested the hypothesis that this variant predicts tumor biology, like other 3’UTR mutations in cancer.
Beschreibung:Gesehen am 12.08.2020
Beschreibung:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-14-421

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