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Prognostic relevance of induced and spontaneous apoptosis of disseminated tumor cells in primary breast cancer patients

An imbalance between cell proliferation and programmed cell death can result in tumor growth. Although most systemic cytotoxic agents induce apoptosis in tumor cells, a high apoptotic rate in primary breast cancer correlates with poor prognosis. The aim of this study was to investigate the incidence...

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Main Authors: Krawczyk, Natalia (Author) , Hartkopf, Andreas (Author) , Banys, Malgorzata (Author) , Meier-Stiegen, Franziska (Author) , Staebler, Annette (Author) , Wallwiener, Markus (Author) , Röhm, Carmen (Author) , Hoffmann, Juergen (Author) , Hahn, Markus (Author) , Fehm, Tanja (Author)
Format: Article (Journal)
Language:English
Published: 3 June 2014
In: BMC cancer
Year: 2014, Volume: 14
ISSN:1471-2407
DOI:10.1186/1471-2407-14-394
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-14-394
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Author Notes:Natalia Krawczyk, Andreas Hartkopf, Malgorzata Banys, Franziska Meier-Stiegen, Annette Staebler, Markus Wallwiener, Carmen Röhm, Juergen Hoffmann, Markus Hahn and Tanja Fehm
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Summary:An imbalance between cell proliferation and programmed cell death can result in tumor growth. Although most systemic cytotoxic agents induce apoptosis in tumor cells, a high apoptotic rate in primary breast cancer correlates with poor prognosis. The aim of this study was to investigate the incidence and the prognostic significance of apoptotic disseminated tumor cells (DTC) in the bone marrow (BM) of breast cancer patients who either underwent primary surgery or primary systemic chemotherapy (PST).
Item Description:Gesehen am 12.08.2020
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-14-394

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