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Prognostic relevance of induced and spontaneous apoptosis of disseminated tumor cells in primary breast cancer patients

An imbalance between cell proliferation and programmed cell death can result in tumor growth. Although most systemic cytotoxic agents induce apoptosis in tumor cells, a high apoptotic rate in primary breast cancer correlates with poor prognosis. The aim of this study was to investigate the incidence...

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Hauptverfasser: Krawczyk, Natalia (VerfasserIn) , Hartkopf, Andreas (VerfasserIn) , Banys, Malgorzata (VerfasserIn) , Meier-Stiegen, Franziska (VerfasserIn) , Staebler, Annette (VerfasserIn) , Wallwiener, Markus (VerfasserIn) , Röhm, Carmen (VerfasserIn) , Hoffmann, Juergen (VerfasserIn) , Hahn, Markus (VerfasserIn) , Fehm, Tanja (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 June 2014
In: BMC cancer
Year: 2014, Jahrgang: 14
ISSN:1471-2407
DOI:10.1186/1471-2407-14-394
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-14-394
Volltext
Verfasserangaben:Natalia Krawczyk, Andreas Hartkopf, Malgorzata Banys, Franziska Meier-Stiegen, Annette Staebler, Markus Wallwiener, Carmen Röhm, Juergen Hoffmann, Markus Hahn and Tanja Fehm
Beschreibung
Zusammenfassung:An imbalance between cell proliferation and programmed cell death can result in tumor growth. Although most systemic cytotoxic agents induce apoptosis in tumor cells, a high apoptotic rate in primary breast cancer correlates with poor prognosis. The aim of this study was to investigate the incidence and the prognostic significance of apoptotic disseminated tumor cells (DTC) in the bone marrow (BM) of breast cancer patients who either underwent primary surgery or primary systemic chemotherapy (PST).
Beschreibung:Gesehen am 12.08.2020
Beschreibung:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-14-394

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