Characteristics of lung cancer after a previous malignancy
Background - In the era of improving overall survival rates of malignant diseases, the impact of a previous malignancy (PM) on treatment and outcome of lung cancer (LC) remains unclear. - Methods - We reviewed all LC patients from our institution that were treated from 2004 to 2006 for the occurrenc...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 March 2014
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| In: |
Respiratory medicine
Year: 2014, Volume: 108, Issue: 6, Pages: 910-917 |
| ISSN: | 1532-3064 |
| DOI: | 10.1016/j.rmed.2014.02.015 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.rmed.2014.02.015 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0954611114000900 
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| Author Notes: | Niels Reinmuth, Patrick Stumpf, Andreas Stumpf, Thomas Muley, Sonja Kobinger, Hans Hoffmann, Felix J. F. Herth, Philipp A. Schnabel, Helge Bischoff, Michael Thomas |
| Summary: | Background - In the era of improving overall survival rates of malignant diseases, the impact of a previous malignancy (PM) on treatment and outcome of lung cancer (LC) remains unclear. - Methods - We reviewed all LC patients from our institution that were treated from 2004 to 2006 for the occurrence of LC with PM excluding patients with multiple primary LC. - Results - A total of 444 and 2698 LC patients with and without a history of a PM were identified (prevalence of 14.1%). PM were most often located in breast (15.5%), prostate (14.9%), bladder (9.0%) and kidney (8.8%). Compared to never smokers, patients with nicotine consumption had more often a cancer history of prostate, gastrointestinal, and the head-neck region. The median interval until diagnosis of LC was 72.2 months (range 0-537 months) with most LC diagnosed 5 years after PM diagnosis. With a similar distribution of histology, stage and localization compared to controls, NSCLC patients with PM and stage IV disease showed a favorable overall survival (p < 0.0001). In contrast, SCLC patients had similar survival curves (n.s.). - Conclusions - A considerable subgroup of LC patients has a history of PM that may indicate a favorable prognostic factor. However, these patients should be treated similar to other LC patients. |
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| Item Description: | Gesehen am 14.08.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1532-3064 |
| DOI: | 10.1016/j.rmed.2014.02.015 |