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Candidate drugs against SARS-CoV-2 and COVID-19

Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that...

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Bibliographic Details
Main Authors: McKee, Dwight L. (Author) , Sternberg, Ariane (Author) , Stange, Ulrike (Author) , Laufer, Stefan (Author) , Naujokat, Cord (Author)
Format: Article (Journal)
Language:English
Published: 29 April 2020
In: Pharmacological research
Year: 2020, Volume: 157
ISSN:1096-1186
DOI:10.1016/j.phrs.2020.104859
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.phrs.2020.104859
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1043661820311671
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Author Notes:Dwight L. McKee, Ariane Sternberg, Ulrike Stange, Stefan Laufer, Cord Naujokat
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Summary:Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2. Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of angiotensin-converting enzyme 2 (ACE2). Blockade of ACE2, the host cell receptor for the S protein of SARS-CoV-2 and inhibition of TMPRSS2, which is required for S protein priming may prevent cell entry of SARS-CoV-2. Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may limit spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic.
Item Description:Gesehen am 17.08.2020
Physical Description:Online Resource
ISSN:1096-1186
DOI:10.1016/j.phrs.2020.104859

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