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Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with a poor prognosis and limited therapeutic options. To aid the development of novel immunological interventions, we studied the breadth, frequency, and tumor-infiltration of naturally occurring CD8+ T-cell responses targ...

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Main Authors: Flecken, Tobias (Author) , Schmidt, Nathalie (Author) , Hild, Sandra (Author) , Gostick, Emma (Author) , Drognitz, Oliver (Author) , Zeiser, Robert (Author) , Schemmer, Peter (Author) , Bruns, Helge (Author) , Eiermann, Thomas (Author) , Price, David A. (Author) , Blum, Hubert E. (Author) , Neumann‐Haefelin, Christoph (Author) , Thimme, Robert (Author)
Format: Article (Journal)
Language:English
Published: 2014
In: Hepatology
Year: 2013, Volume: 59, Issue: 4, Pages: 1415-1426
ISSN:1527-3350
DOI:10.1002/hep.26731
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/hep.26731
Verlag, lizenzpflichtig, Volltext: https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.26731
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Author Notes:Tobias Flecken, Nathalie Schmidt, Sandra Hild, Emma Gostick, Oliver Drognitz, Robert Zeiser, Peter Schemmer, Helge Bruns, Thomas Eiermann, David A. Price, Hubert E. Blum, Christoph Neumann‐Haefelin, and Robert Thimme
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Summary:Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with a poor prognosis and limited therapeutic options. To aid the development of novel immunological interventions, we studied the breadth, frequency, and tumor-infiltration of naturally occurring CD8+ T-cell responses targeting several tumor-associated antigens (TAA).
Item Description:First published: 03 September 2013
Gesehen am 18.08.2020
Physical Description:Online Resource
ISSN:1527-3350
DOI:10.1002/hep.26731

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