Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with a poor prognosis and limited therapeutic options. To aid the development of novel immunological interventions, we studied the breadth, frequency, and tumor-infiltration of naturally occurring CD8+ T-cell responses targ...

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Hauptverfasser: Flecken, Tobias (VerfasserIn) , Schmidt, Nathalie (VerfasserIn) , Hild, Sandra (VerfasserIn) , Gostick, Emma (VerfasserIn) , Drognitz, Oliver (VerfasserIn) , Zeiser, Robert (VerfasserIn) , Schemmer, Peter (VerfasserIn) , Bruns, Helge (VerfasserIn) , Eiermann, Thomas (VerfasserIn) , Price, David A. (VerfasserIn) , Blum, Hubert E. (VerfasserIn) , Neumann‐Haefelin, Christoph (VerfasserIn) , Thimme, Robert (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2014
In: Hepatology
Year: 2013, Jahrgang: 59, Heft: 4, Pages: 1415-1426
ISSN:1527-3350
DOI:10.1002/hep.26731
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/hep.26731
Verlag, lizenzpflichtig, Volltext: https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.26731
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Verfasserangaben:Tobias Flecken, Nathalie Schmidt, Sandra Hild, Emma Gostick, Oliver Drognitz, Robert Zeiser, Peter Schemmer, Helge Bruns, Thomas Eiermann, David A. Price, Hubert E. Blum, Christoph Neumann‐Haefelin, and Robert Thimme
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Zusammenfassung:Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with a poor prognosis and limited therapeutic options. To aid the development of novel immunological interventions, we studied the breadth, frequency, and tumor-infiltration of naturally occurring CD8+ T-cell responses targeting several tumor-associated antigens (TAA).
Beschreibung:First published: 03 September 2013
Gesehen am 18.08.2020
Beschreibung:Online Resource
ISSN:1527-3350
DOI:10.1002/hep.26731