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Individual and joint contributions of genetic and methylation risk scores for enhancing lung cancer risk stratification: data from a population-based cohort in Germany

Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional consideration of genetic risk scores (GRSs) and epigenetic risk scores defined by DNA methylation.

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Bibliographic Details
Main Authors: Yu, Haixin (Author) , Schöttker, Ben (Author) , Holleczek, Bernd (Author) , Zhang, Yan (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 18 June 2020
In: Clinical epigenetics
Year: 2020, Volume: 12
ISSN:1868-7083
DOI:10.1186/s13148-020-00872-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13148-020-00872-y
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Author Notes:Haixin Yu, Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Yan Zhang and Hermann Brenner
Description
Summary:Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional consideration of genetic risk scores (GRSs) and epigenetic risk scores defined by DNA methylation.
Item Description:Gesehen am 18.08.2020
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-020-00872-y

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