Synthesis of functionalized chromones through sequential reactions in aqueous media
An efficient sequential four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols is reported which leads to 5a-i in aqueous media. Replacing the primary alcohol with isopropyl alcohol and tert-butyl alcohol results...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 May 2014
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| In: |
Organic & biomolecular chemistry
Year: 2014, Volume: 12, Issue: 30, Pages: 5757-5765 |
| ISSN: | 1477-0539 |
| DOI: | 10.1039/C4OB00618F |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C4OB00618F Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2014/ob/c4ob00618f 
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| Author Notes: | Saber Mehrparvar, Saeed Balalaie, Mahnaz Rabbanizadeh, Frank Rominger and Elmira Ghabraie |
| Summary: | An efficient sequential four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols is reported which leads to 5a-i in aqueous media. Replacing the primary alcohol with isopropyl alcohol and tert-butyl alcohol results in different products 10 and 11. The environmentally friendly features, good to high yields and easy work-up are advantages of this approach. |
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| Item Description: | Gesehen am 24.08.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1477-0539 |
| DOI: | 10.1039/C4OB00618F |