Synthesis of functionalized chromones through sequential reactions in aqueous media

An efficient sequential four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols is reported which leads to 5a-i in aqueous media. Replacing the primary alcohol with isopropyl alcohol and tert-butyl alcohol results...

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Bibliographic Details
Main Authors: Mehrparvar, Saber (Author) , Balalaie, Saeed (Author) , Rabbanizadeh, Mahnaz (Author) , Rominger, Frank (Author) , Ghabraie, Elmira (Author)
Format: Article (Journal)
Language:English
Published: 29 May 2014
In: Organic & biomolecular chemistry
Year: 2014, Volume: 12, Issue: 30, Pages: 5757-5765
ISSN:1477-0539
DOI:10.1039/C4OB00618F
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C4OB00618F
Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2014/ob/c4ob00618f
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Author Notes:Saber Mehrparvar, Saeed Balalaie, Mahnaz Rabbanizadeh, Frank Rominger and Elmira Ghabraie
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Summary:An efficient sequential four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols is reported which leads to 5a-i in aqueous media. Replacing the primary alcohol with isopropyl alcohol and tert-butyl alcohol results in different products 10 and 11. The environmentally friendly features, good to high yields and easy work-up are advantages of this approach.
Item Description:Gesehen am 24.08.2020
Physical Description:Online Resource
ISSN:1477-0539
DOI:10.1039/C4OB00618F