Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis
Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption and therefore iron Overload. iron overload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress and lipid peroxidation. The impact of iron o...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 July 2020
|
| In: |
BMC gastroenterology
Year: 2020, Volume: 20 |
| ISSN: | 1471-230X |
| DOI: | 10.1186/s12876-020-01282-3 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12876-020-01282-3
|
| Author Notes: | Jessica Seeßle, Hongying Gan-Schreier, Marietta Kirchner, Wolfgang Stremmel, Walee Chamulitrat and Uta Merle |
| Summary: | Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption and therefore iron Overload. iron overload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress and lipid peroxidation. The impact of iron on lipid metabolism is so far not fully understood. The aim of this study was to investigate lipid metabolism including lipoproteins (HDL, LDL), neutral (triglycerides, cholesterol) and polar lipids (sphingo- and phospholipids), and PNPLA3 polymorphism (rs738409/I148M) in HH. |
|---|---|
| Item Description: | Gesehen am 25.08.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1471-230X |
| DOI: | 10.1186/s12876-020-01282-3 |