Buchumschlag

Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis

Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption and therefore iron Overload. iron overload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress and lipid peroxidation. The impact of iron o...

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Bibliographische Detailangaben
Hauptverfasser: Seeßle, Jessica (VerfasserIn) , Gan-Schreier, Hongying (VerfasserIn) , Kirchner, Marietta (VerfasserIn) , Stremmel, Wolfgang (VerfasserIn) , Chamulitrat, Walee (VerfasserIn) , Merle, Uta (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 July 2020
In: BMC gastroenterology
Year: 2020, Jahrgang: 20
ISSN:1471-230X
DOI:10.1186/s12876-020-01282-3
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12876-020-01282-3
Volltext
Verfasserangaben:Jessica Seeßle, Hongying Gan-Schreier, Marietta Kirchner, Wolfgang Stremmel, Walee Chamulitrat and Uta Merle
Beschreibung
Zusammenfassung:Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption and therefore iron Overload. iron overload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress and lipid peroxidation. The impact of iron on lipid metabolism is so far not fully understood. The aim of this study was to investigate lipid metabolism including lipoproteins (HDL, LDL), neutral (triglycerides, cholesterol) and polar lipids (sphingo- and phospholipids), and PNPLA3 polymorphism (rs738409/I148M) in HH.
Beschreibung:Gesehen am 25.08.2020
Beschreibung:Online Resource
ISSN:1471-230X
DOI:10.1186/s12876-020-01282-3

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