Preoperative vitamin D supplementation in patients with vitamin D deficiency undergoing total thyroidectomy
Background - Transient hypocalcemia due to parathyroid gland or vessel manipulation is a common complication following thyroidectomy. Considering the role of 25-hydroxyvitamin D (25(OH)D) in calcium hemostasis, this study aimed to evaluate the effect of preoperative vitamin D supplementation on hypo...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
6 May 2020
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| In: |
The American journal of the medical sciences
Year: 2020, Volume: 360, Issue: 2, Pages: 146-152 |
| ISSN: | 1538-2990 |
| DOI: | 10.1016/j.amjms.2020.04.036 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.amjms.2020.04.036 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0002962920301695 
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| Author Notes: | Ali Ramouz, MD, Mahdie Hosseini, MD, Seyedeh Shaghayegh Hosseinzadeh, MD, Seyed Ziaeddin Rasihashemi, MD |
| Summary: | Background - Transient hypocalcemia due to parathyroid gland or vessel manipulation is a common complication following thyroidectomy. Considering the role of 25-hydroxyvitamin D (25(OH)D) in calcium hemostasis, this study aimed to evaluate the effect of preoperative vitamin D supplementation on hypocalcemia incidence in thyroidectomy patients. - Methods - In this randomized clinical trial, 100 patients scheduled for total thyroidectomy and suffering from preoperative moderate or severe vitamin D deficiency were enrolled. Patients were randomly allocated to either study or control groups using the sealed envelope method. Patients in the study group received vitamin D3 50,000-unit pearl weekly for 4 weeks prior to the operation. The control group received placebo. Total and ionized serum calcium levels were checked before surgery, the day after surgery, and 2 weeks postoperatively. - Results - No significant difference was observed in terms of demographic data. During serial total calcium checks (5 episodes), total calcium levels changed significantly in patients who had received vitamin D supplements compared to the control group (P = 0.043). Symptomatic hypocalcemia incidence was significantly lower in patients supplemented with 25-hydroxyvitamin D (25(OH)D) (P = 0.04). Also, the requirement for intravenous calcium administration in order to treat the hypocalcemia symptoms was significantly lower in the study in comparison to the control group (P = 0.03). - Conclusions - Vitamin D supplementation in patients with vitamin D deficiency might lead to a lower incidence of early-onset symptomatic hypocalcemia; hence, requiring less calcium supplementation for the management of hypocalcemia. |
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| Item Description: | Gesehen am 25.08.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1538-2990 |
| DOI: | 10.1016/j.amjms.2020.04.036 |