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New strategies in prostate cancer: prostate-specific membrane antigen (PSMA) ligands for diagnosis and therapy

Key issues for prostate cancer patients are the detection of recurrent disease and the treatment of metastasized cancer. Early detection is a major challenge for all conventional imaging modalities. Furthermore, therapy of patients with hormone-resistant tumor lesions presents a major clinical chall...

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Bibliographic Details
Main Authors: Haberkorn, Uwe (Author) , Eder, Matthias (Author) , Kopka, Klaus (Author) , Babich, John W. (Author) , Eisenhut, Michael (Author)
Format: Article (Journal)
Language:English
Published: January 2016
In: Clinical cancer research
Year: 2016, Volume: 22, Issue: 1, Pages: 9-15
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-15-0820
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-15-0820
Verlag, lizenzpflichtig, Volltext: https://clincancerres.aacrjournals.org/content/22/1/9
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Author Notes:Uwe Haberkorn, Matthias Eder, Klaus Kopka, John W. Babich, and Michael Eisenhut
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Summary:Key issues for prostate cancer patients are the detection of recurrent disease and the treatment of metastasized cancer. Early detection is a major challenge for all conventional imaging modalities. Furthermore, therapy of patients with hormone-resistant tumor lesions presents a major clinical challenge. Because the prostate-specific membrane antigen (PSMA) is frequently overexpressed in prostate cancer, several PSMA-targeting molecules are under development to detect and treat metastatic castration-resistant prostate cancer (mCRPC). mCRPC represents a situation where cure is no longer achievable and novel therapeutic approaches for palliation and increase of survival are needed. In this article, we discuss the recent development for noninvasive detection of recurrent disease and therapy of mCRPC with corresponding PSMA-targeted radioligands. Clin Cancer Res; 22(1); 9-15. ©2016 AACR.
Item Description:Gesehen am 02.09.2020
Physical Description:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-15-0820

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