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Mechanistic investigation of the nickel-catalyzed carbonylation of alcohols

The carbonylation of alcohols represents a straightforward and atom-efficient methodology for the preparation of carboxylic acids. It is desirable to perform these reactions under precious metal-free and low-pressure conditions, with regioselectivity control. In this work, we present a detailed mech...

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Main Authors: Sabater, Sara (Author) , Menche, Maximilian (Author) , Ghosh, Tamal (Author) , Krieg, Saskia (Author) , Rück, Katharina S. L. (Author) , Paciello, Rocco (Author) , Schäfer, Ansgar (Author) , Comba, Peter (Author) , Hashmi, A. Stephen K. (Author) , Schaub, Thomas (Author)
Format: Article (Journal)
Language:English
Published: March 6, 2020
In: Organometallics
Year: 2020, Volume: 39, Issue: 6, Pages: 870-880
ISSN:1520-6041
DOI:10.1021/acs.organomet.0c00082
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.organomet.0c00082
Verlag, lizenzpflichtig, Volltext: https://pubs.acs.org/doi/10.1021/acs.organomet.0c00082
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Author Notes:Sara Sabater, Maximilian Menche, Tamal Ghosh, Saskia Krieg, Katharina S. L. Rück, Rocco Paciello, Ansgar Schäfer, Peter Comba, A. Stephen K. Hashmi, and Thomas Schaub
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Summary:The carbonylation of alcohols represents a straightforward and atom-efficient methodology for the preparation of carboxylic acids. It is desirable to perform these reactions under precious metal-free and low-pressure conditions, with regioselectivity control. In this work, we present a detailed mechanistic study of a catalytic system based on NiI2, which can carbonylate benzylic alcohols in a highly regioselective manner to the corresponding branched carboxylic acids, core motifs for nonsteroidal drugs.
Item Description:Gesehen am 02.09.2020
Physical Description:Online Resource
ISSN:1520-6041
DOI:10.1021/acs.organomet.0c00082

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