Sphingolipids as modulators of membrane proteins
The diversity of the transmembranome of higher eukaryotes is matched by an enormous diversity of sphingolipid classes and molecular species. The intrinsic properties of sphingolipids are not only suited for orchestrating lateral architectures of biological membranes, but their molecular distinctions...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2014
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| In: |
Biochimica et biophysica acta. Molecular and cell biology of lipids
Year: 2013, Volume: 1841, Issue: 5, Pages: 665-670 |
| ISSN: | 1879-2618 |
| DOI: | 10.1016/j.bbalip.2013.10.016 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bbalip.2013.10.016 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1388198113002394 
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| Author Notes: | Andreas Max Ernst, Britta Brügger |
| Summary: | The diversity of the transmembranome of higher eukaryotes is matched by an enormous diversity of sphingolipid classes and molecular species. The intrinsic properties of sphingolipids are not only suited for orchestrating lateral architectures of biological membranes, but their molecular distinctions also allow for the evolution of protein motifs specifically recognising and interacting with individual lipids. Although various reports suggest a role of sphingolipids in membrane protein function, only a few cases have determined the specificity of these interactions. In this review we discuss examples of specific protein-sphingolipid interactions for which a modulator-like dependency on sphingolipids was assigned to specific proteins. These novel functions of sphingolipids in specific protein-lipid assemblies contribute to the complexity of the sphingolipid classes and other molecular species observed in animal cells. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. |
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| Item Description: | Gesehen am 03.09.2020 First published: 5 November 2013 |
| Physical Description: | Online Resource |
| ISSN: | 1879-2618 |
| DOI: | 10.1016/j.bbalip.2013.10.016 |